abstract：:Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...

journal_title：Stem cells international

authors： Ni Y,Cai K,Hu Y,Wang CH,Zhang Y,Huang H,Su X,Gu JH

更新日期：2018-04-05 00:00:00

abstract：Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...

journal_title：Stem cells international

authors： Zhang L,Zheng F,Peng Z,Hu Z,Yang Z

更新日期：2018-04-03 00:00:00

abstract：:Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...

journal_title：Stem cells international

authors： Kaur G,Cai C

更新日期：2018-03-29 00:00:00

abstract：:Human eyelid adipose-derived stem cells (HEASCs) are a new source of autologous mesenchymal stem cells, which are derived from neuroectoderm and potentially applied in the tissue regeneration and cell therapies. Based on the prevalence of blepharoplasty in Asia and the availability of HEASCs, we investigated the effec...

journal_title：Stem cells international

authors： Zhang M,Wang Z,Zhao Y,Zhang L,Xu L,Cao L,He W

更新日期：2018-03-19 00:00:00

abstract：:Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem ce...

journal_title：Stem cells international

authors： Cappetta D,De Angelis A,Spaziano G,Tartaglione G,Piegari E,Esposito G,Ciuffreda LP,Liparulo A,Sgambato M,Russo TP,Rossi F,Berrino L,Urbanek K,D'Agostino B

更新日期：2018-03-14 00:00:00

abstract：:Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...

journal_title：Stem cells international

authors： Sassoli C,Pierucci F,Tani A,Frati A,Chellini F,Matteini F,Vestri A,Anderloni G,Nosi D,Zecchi-Orlandini S,Meacci E

更新日期：2018-03-11 00:00:00

abstract：:Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...

journal_title：Stem cells international

authors： Posa F,Di Benedetto A,Cavalcanti-Adam EA,Colaianni G,Porro C,Trotta T,Brunetti G,Lo Muzio L,Grano M,Mori G

更新日期：2018-02-28 00:00:00

abstract：Objective:Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated the hypothesis that hypoxic preconditioning (HP) could improve the therapeutic effect of bone mesenchymal stem cells (BMSCs) to IVD degeneration. Methods:BMSC...

journal_title：Stem cells international

authors： Wang W,Wang Y,Deng G,Ma J,Huang X,Yu J,Xi Y,Ye X

更新日期：2018-02-14 00:00:00

abstract：:Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...

journal_title：Stem cells international

authors： Pogozhykh O,Prokopyuk V,Figueiredo C,Pogozhykh D

更新日期：2018-01-18 00:00:00

abstract：:We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led to the expression of a mature and functional CFTR protein. In order to explore the role of gap junction-...

journal_title：Stem cells international

authors： Carbone A,Zefferino R,Beccia E,Casavola V,Castellani S,Di Gioia S,Giannone V,Seia M,Angiolillo A,Colombo C,Favia M,Conese M

更新日期：2018-01-11 00:00:00

abstract：:The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...

journal_title：Stem cells international

authors： Frati P,Scopetti M,Santurro A,Gatto V,Fineschi V

更新日期：2017-01-01 00:00:00

abstract：:Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of gene expression. However, the specific roles of lncRNAs in stenotic lesions of arteriovenous fistula (AVF) failure are still largely unknown. We first analyzed the expression profiles of lncRNAs in human stenosed and n...

journal_title：Stem cells international

authors： Lv L,Qi H,Guo X,Ni Q,Yan Z,Zhang L

更新日期：2017-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in cell fate decisions. However, the miRNAs and their targets involved in the regulation of cardiac lineage specification are largely unexplored. Here, we report novel functions of miR-142-3p in the regulation of cardiomyocyte differentiation from mouse embryonic stem cells (mES...

journal_title：Stem cells international

authors： Chen ZY,Chen F,Cao N,Zhou ZW,Yang HT

更新日期：2017-01-01 00:00:00

abstract：:Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuse...

journal_title：Stem cells international

authors： Salehi-Nik N,Rezai Rad M,Kheiri L,Nazeman P,Nadjmi N,Khojasteh A

更新日期：2017-01-01 00:00:00

abstract：:Mutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WD...

journal_title：Stem cells international

authors： Alshawaf AJ,Antonic A,Skafidas E,Ng DC,Dottori M

更新日期：2017-01-01 00:00:00

abstract：:A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...

journal_title：Stem cells international

authors： Bianchi M,Pisciotta A,Bertoni L,Berni M,Gambardella A,Visani A,Russo A,de Pol A,Carnevale G

更新日期：2017-01-01 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. HSCT procedure involves important ethical and legal aspects that can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretranspla...

journal_title：Stem cells international

authors： Liso A,Neri M,Maglietta F,La Russa R,Turillazzi E

更新日期：2017-01-01 00:00:00

abstract：:In cholestatic liver diseases, impaired bile excretion disrupts lipid homeostasis. We investigated changes of lipid metabolism, including mitochondrial β-oxidation, in a rat model of bile duct ligation (BDL) in which chorionic plate-derived mesenchymal stem cells (CP-MSCs) were transplanted. Serum cholesterol level, w...

journal_title：Stem cells international

authors： Lee YB,Choi JH,Kim EN,Seok J,Lee HJ,Yoon JH,Kim GJ

更新日期：2017-01-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...

journal_title：Stem cells international

authors： Mellado-López M,Griffeth RJ,Meseguer-Ripolles J,Cugat R,García M,Moreno-Manzano V

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the saf...

journal_title：Stem cells international

authors： Oliveira RL,Chagastelles PC,Sesterheim P,Pranke P

更新日期：2017-01-01 00:00:00

abstract：:Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...

journal_title：Stem cells international

authors： Xu L,Zhou J,Liu J,Liu Y,Wang L,Jiang R,Diao Z,Yan G,Pèault B,Sun H,Ding L

更新日期：2017-01-01 00:00:00

abstract：:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highl...

journal_title：Stem cells international

authors： Lees JG,Gardner DK,Harvey AJ

更新日期：2017-01-01 00:00:00

abstract：:Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues i...

journal_title：Stem cells international

authors： Qu J,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Objectives. Acute lung injury (ALI) is a common clinical critical disease. Stem cells transplantation is recognized as an effective way to repair injured lung tissues. The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on repair of lung and its mechanism. Methods. MSCs carrying GFP...

journal_title：Stem cells international

authors： Xin X,Yan L,Guangfa Z,Yan H,Keng L,Chunting W

更新日期：2017-01-01 00:00:00

abstract：:Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modula...

journal_title：Stem cells international

authors： Souza BSF,da Silva KN,Silva DN,Rocha VPC,Paredes BD,Azevedo CM,Nonaka CK,Carvalho GB,Vasconcelos JF,Dos Santos RR,Soares MBP

更新日期：2017-01-01 00:00:00

abstract：:Endometriosis is an inflammatory disease with predominance of immunosuppressive M2 macrophages in the pelvic cavity that could be involved in the pathology through support and immune escape of ectopic lesions. Mesenchymal stromal cells (MSC) are found in ectopic lesions, and MSC from nonendometriosis sources are known...

journal_title：Stem cells international

authors： Abomaray F,Gidlöf S,Götherström C

更新日期：2017-01-01 00:00:00

abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...

journal_title：Stem cells international

authors： Guo H,Lei M,Li Y,Liu Y,Tang Y,Xing Y,Deng F,Yang K

更新日期：2017-01-01 00:00:00

abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...

journal_title：Stem cells international

authors： Gjorevski N,Ordóñez-Morán P

更新日期：2017-01-01 00:00:00

abstract：:Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and improved clinical o...

journal_title：Stem cells international

authors： Simard T,Jung RG,Motazedian P,Di Santo P,Ramirez FD,Russo JJ,Labinaz A,Yousef A,Anantharam B,Pourdjabbar A,Hibbert B

更新日期：2017-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/3978595.]. ...

journal_title：Stem cells international

authors： Zadroga A,Jezierska-Woźniak K,Czarzasta J,Barczewska M,Wojtkiewicz J,Maksymowicz W

更新日期：2017-01-01 00:00:00

abstract：Purpose:To determine the effect of the isolation technique and location upon the phenotype of human corneal stroma-derived cells (CSCs). Methods:CSCs were isolated from the corneal stroma center and periphery using the explant or enzymatic digestion technique. The native tissue was stained for functional markers, whil...

journal_title：Stem cells international

authors： Nagymihály R,Veréb Z,Facskó A,Moe MC,Petrovski G

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) offering valuable anticipations for the treatment of degenerative diseases. They can be found in many tissues including amnion. MSCs from amnion (AM-MSCs) can differentiate into osteoblast similar to that of bone marrow-derived MSCs (BM-MSCs). However, the ability is not much efficient...

journal_title：Stem cells international

authors： Manochantr S,Marupanthorn K,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Sanguanjit P

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. ...

journal_title：Stem cells international

authors： Chijimatsu R,Ikeya M,Yasui Y,Ikeda Y,Ebina K,Moriguchi Y,Shimomura K,Hart DA,Hideki Y,Norimasa N

更新日期：2017-01-01 00:00:00

abstract：:Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...

journal_title：Stem cells international

authors： Cheng Q,Li X,Liu J,Ye Q,Chen Y,Tan S,Liu J

更新日期：2017-01-01 00:00:00

abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...

journal_title：Stem cells international

authors： Solders M,Gorchs L,Gidlöf S,Tiblad E,Lundell AC,Kaipe H

更新日期：2017-01-01 00:00:00

abstract：:Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translat...

journal_title：Stem cells international

authors： Horák J,Nalos L,Martínková V,Beneš J,Štengl M,Matějovič M

更新日期：2017-01-01 00:00:00

abstract：:Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was a...

journal_title：Stem cells international

authors： Blázquez-Prunera A,Almeida CR,Barbosa MA

更新日期：2017-01-01 00:00:00

abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...

journal_title：Stem cells international

authors： Cimino M,Gonçalves RM,Barrias CC,Martins MCL

更新日期：2017-01-01 00:00:00

abstract：:Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...

journal_title：Stem cells international

authors： Churchman SM,Boxall SA,McGonagle D,Jones EA

更新日期：2017-01-01 00:00:00

abstract：:The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of ster...

journal_title：Stem cells international

authors： Aluri HS,Samizadeh M,Edman MC,Hawley DR,Armaos HL,Janga SR,Meng Z,Sendra VG,Hamrah P,Kublin CL,Hamm-Alvarez SF,Zoukhri D

更新日期：2017-01-01 00:00:00